Disease Modeling

The study of disease has been hampered by a lack of in vitro models that correlate with clinical data. Researchers have traditionally relied on animal or tumor-derived cells, lines immortalized through genetic modification, or difficult to obtain primary tissue. The advent of iPS cells has drastically changed the field by providing a simple platform to study a wide range of human diseases and to screen novel drugs to treat them. Read more about the advantages of iPSC-derived disease models.

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How will you use iPSCs for your own disease modeling?

Our differentiation technology allows for fast, footprint-free differentiation of both healthy control and diseased patient iPSCs, allowing for scalable, robust, and reproducible models in a wide array of diseases.

Elixirgen Scientific is committed to supporting your research. Application of our iPSC differentiation technology provides a better way to model human biology with genetically-identical human cells. Our differentiation technology is rapid, reliable, and reproducible results. Harness the advantages of our technology to differentiate iPSC-derived cells into a range of disease lines.

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  • ~ 1 month differentiation
  • Functionally validated
  • No genetic footprint
  • Differentiation Kits and Differentiated Cells available
  • Multiple donors and disease types available

Disease Modeling Examples

Elixirgen Scientific's Products at Work

ALS Disease Modeling with Cholinergic neurons differentiated to a Healthy Control and ALS patient from iPSC.

Figure 1: Cholinergic neurons differentiated, using Elixirgen's CH-SeV differentiation kit, from ALS patient-derived iPSCs (with TDP-43 mutation) show aggregation of TDP-43 in cytoplasm

Figure 2: Mixed neurons differentiated from both a control patient and an Alzheimer’s Disease (AD) affected patient using Elixirgen's mixed neuron Sendai virus kit (A) qRT-PCR data 15 days post differentiation (B)  ELISA data shows amounts of Aβ and Tau protein after 6 weeks of culture

Figure 3: Skeletal muscle cells differentiated (using Elixirgen's Differentiation Service) from Myotonic Dystrophy Type I  (DM-03) and gene-corrected (J-6) patient-derived iPSCs provided by a customer. Cells derived from the DMD1 patient exhibit disease-associated phenotypes (on DM-03 nuclei, A, C). Loss of disease-associated RNA foci was observed after correction of the mutation (on J-6 nuclei: B, D).

Source: Wang et.al., Molecular Therapy (Nov 2018)

iPSC Differentiation Kits

Our Differentiation Kits (small and large sizes available) allow researchers to quickly, easily, and efficiently differentiate iPSC-derived cells into a vast amount of disease types and healthy controls. Human induced pluripotent stem cells (iPSCs) are a powerful tool for studying neuronal activity in vitro. The kits utilize our proprietary cocktail of transcription factors that induce differentiation without leaving a genetic footprint.

iPSC Differentiation Services

At Elixirgen Scientific, our expert team can provide quality iPSC services in just 4 easy steps. When you trust our team with your differentiation services, our support for your project starts with a free design consultation. One of our scientists will provide a thorough consultation with your lab to customize the scope of the project. Your assigned case representative will be readily available to answer questions throughout every step.

iPSC Differentiation Technology

Transcription-factor Based iPSC Differentiation

Our proprietary technology is licensed to Elixirgen Scientific. The transcription-factor based approach enables the advantages of our products and services. The technology provides high-quality iPSC-derived cells to have limitless opportunities as a biomedical tool such as disease modeling.

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